Author: Tanusree Naskar
DOI Link: https://doi.org/10.70798/Bijmrd/03110031
Abstract: Acute Myeloid Leukemia (AML) is a highly aggressive hematologic malignancy characterized by uncontrolled proliferation and impaired differentiation of myeloid progenitors. Diallyl Disulfide (DADS), a bioactive organosulfur compound derived from garlic (Allium sativum), has emerged as a potent antileukemic agent due to its ability to induce apoptosis in AML cells. This review comprehensively examines the molecular mechanisms underlying DADS-mediated cell death, including reactive oxygen species (ROS) generation, activation of intrinsic caspase cascades, inhibition of survival pathways such as EGFR/ERK/PKM2 and mTOR, and induction of autophagy. In addition, DADS demonstrates synergistic apoptotic effects when combined with bioactive compounds and chemotherapeutic agents, while selectively sparing normal hematopoietic cells. Beyond apoptosis, DADS promotes differentiation and inhibits proliferation in leukemic cells, further contributing to its anti-leukemic potential. Collectively, these findings highlight DADS as a multifaceted therapeutic candidate capable of targeting chemoresistant and stem-like AML cells. Further investigation is warranted to optimize its clinical application and develop effective combination strategies.
Keywords: Diallyl Disulfide, Apoptosis, Acute Myeloid Leukemia, Reactive Oxygen Species, Leukemic Stem Cells.
Page No: 255-262